Custom Peptides
Cayman Chemical Curcuma zdoara Grmacron 10mg
A sesquiterpene with diverse biological activities; inhibits PRV replication in Vero cells from 10-150 µM; enhances doxorubicin-induced cytotoxicity and apoptosis in doxorubicin-resistant MCF-7/adr cells from 50-250 µM; reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity at 5, 10, and 20 mg/kg; decreases brain MDA levels and activity of SOD and GPX, as well as reduces infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical Peficitinib 10MG
A JAK inhibitor (IC50s = 3.9, 5, and 0.71 nM for JAK1-3, respectively); 14-fold selective for JAK1 and JAK3 over JAK2 in erythropoietin-induced leukemia cell proliferation assays; inhibits IL-2-induced proliferation of rat splenocytes (IC50 = 10 nM) and phosphorylation of STAT5 in rat and human whole blood (IC50s = 124 and 127 nM, respectively); reduces paw swelling (ED50 = 5.6 mg/kg) and bone destruction in a rat model of adjuvant-induced arthritis at 30 mg/kg
Cayman Chemical TazarotenIc AcId 10mg
An RAR agonist and an active metabolite of tazarotene; induces reporter gene expression in DK7-NR cells expressing human RARα, RARβ, or RARγ (EC50s = 11, 2.5, and 11 nM, respectively); reduces EAr edema in a PMA-induced mouse model of epidermal inflammation when applied topically at 0.1% w/w
Cayman Chemical 17phenyl TRNor PROSGlndI 10mg
A form of 17-phenyl trinor PGF modified with a cyclohexane moiety at the alpha carbon; insoluble in aqueous media, soluble in organic solvents; activity at the FP receptor has not been evaluated
Cayman Chemical JWH398 7CLORNaphthyl Isom 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical PetunIdInchlorIde 10mg
An O-methylated anthocyanidin that imparts blue-red pigments to flowers, fruits, and red wine; suppresses the activity of focal adhesion kinase and the proliferation of HCT116 colon cancer cells
Cayman Chemical n1177trIfluoroacetAT salt 10mg
A dual peptide GCGR and GLP-1R agonist; induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s = 1.83 and 0.92 pM, respectively); reduces body weight and cumulative food intake in a mouse model of diet-induced obesity from 3-5 nmol/kg; reduces body weight, hepatic fat accumulation and fibrosis, and plasma ALT levels in a mouse model of NASH induced by a high-fat, high-fructose, and high-cholesterol diet
Cayman Chemical S-2 MethndamIde 10mg
The second most potent CB1 receptor agonist in the methanandamide series (Ki = 26 nM for the CB1 receptor); less prone to FAAH inactivation and inhibits the murine vas deferens twitch response (IC50 = 47 nM)
Cayman Chemical 4-MethylumbelIferylD-N N 10mg
A fluorogenic substrate for chitinases and chitotriosidases; ex = 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively; em = 445-455 nm, increasing as pH decreases; has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders
Cayman Chemical JWH 018 7hydroxyIndl meta 10mg
A minor urinary metabolite of JWH 018; intended for research and forensic applications
Cayman Chemical CGP 77675hydrate 10mg
An inhibitor of Src family kinases that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively); also inhibits Lck and c-Yes with low nanomolar IC50 values
Cayman Chemical Cholyl-putrescIn 10mg
A polyamine bile amidate; has been found in lion and mouse, as well as serval, cheetah, and tiger fecal samples; has been used as a standard for the detection of endogenous bile acid amidates in mammalian intestinal and fecal samples
Cayman Chemical CARFILZOMIB 10MG
An irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM)
Cayman Chemical BalsalazIde 10mg
A prodrug form of 5-ASA; cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA; decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of DNCB-induced colitis at 600 mg/kg per day
Cayman Chemical SynthetIc MoracIn M 10mg
A polyphenol with diverse biological activities; inhibits PDE4D2 and PDE4B2 (IC50s = 1.9 and 4.5 µM, respectively); induces cell death in P388 cells (IC50 = 24.8 µM); inhibits IL-1β-induced increases in the levels of phosphorylated ERK and JNK in A549 cells at 30 or 50 µM; inhibits LPS-induced increases in NO and iNOS levels in MH-S macrophages at 50 and 60 µM, respectively; inhibits LPS-induced increases in the number of neutrophils, alveolar macrophages, and dendritic cells in BALF, the thickness of alveolar walls, and the levels of NF-κB in the lungs in a rat model of acute lung injury at 60 mg/kg